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aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, ß-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.
Molinar-Inglis, Olivia; Birch, Cierra A; Nicholas, Dequina; Orduña-Castillo, Lennis; Cisneros-Aguirre, Metztli; Patwardhan, Anand; Chen, Buxin; Grimsey, Neil J; Coronel, Luisa J; Lin, Huilan; Gomez Menzies, Patrick K; Lawson, Mark A; Patel, Hemal H; Trejo, JoAnn.
Afiliación
  • Molinar-Inglis O; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Birch CA; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Nicholas D; Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, CA 92697.
  • Orduña-Castillo L; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Cisneros-Aguirre M; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Patwardhan A; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Chen B; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Grimsey NJ; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Coronel LJ; Department of Pharmaceutical Sciences and Biomedical Sciences, School of Pharmacy, University of Georgia, Athens, GA 30682.
  • Lin H; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Gomez Menzies PK; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Lawson MA; Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Patel HH; Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California San Diego, La Jolla, CA 92093.
  • Trejo J; VA San Diego Health Care System, San Diego, CA 92161.
Proc Natl Acad Sci U S A ; 118(49)2021 12 07.
Article en En | MEDLINE | ID: mdl-34873055
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína C / Fosfotransferasas (Aceptor de Grupo Alcohol) / Receptor PAR-1 / Proteínas Proto-Oncogénicas c-akt / Arrestina beta 2 / Receptores de Esfingosina-1-Fosfato Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína C / Fosfotransferasas (Aceptor de Grupo Alcohol) / Receptor PAR-1 / Proteínas Proto-Oncogénicas c-akt / Arrestina beta 2 / Receptores de Esfingosina-1-Fosfato Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article