Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly.

Congdon, Erin E; Jiang, Yixiang; Sigurdsson, Einar M

Congdon, Erin E; Jiang, Yixiang; Sigurdsson, Einar M.

Afiliación

Congdon EE; Department of Neuroscience and Physiology, Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: erin.congdon@nyulangone.org.
Jiang Y; Department of Neuroscience and Physiology, Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, United States.
Sigurdsson EM; Department of Neuroscience and Physiology, Neuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016, United States; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: einar.sigurdsson@nyulangone.org.

Semin Cell Dev Biol ; 126: 125-137, 2022 06.

Article en En | MEDLINE | ID: mdl-34896021

Asunto(s)

Enfermedad de Alzheimer; Inmunoterapia; Tauopatías; Proteínas tau; Enfermedad de Alzheimer/metabolismo; Anticuerpos/uso terapéutico; Humanos; Inmunoterapia/métodos; Neuronas/metabolismo; Tauopatías/tratamiento farmacológico; Tauopatías/metabolismo; Tauopatías/patología; Proteínas tau/inmunología; Proteínas tau/metabolismo

Palabras clave

Active immunization; Alzheimer's disease; Antibodies; Immunotherapies; Passive immunization; Tau protein; Tauopathies

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas tau / Tauopatías / Enfermedad de Alzheimer / Inmunoterapia Límite: Humans Idioma: En Revista: Semin Cell Dev Biol Asunto de la revista: EMBRIOLOGIA Año: 2022 Tipo del documento: Article

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