Effect of Rhus coriaria L. methanolic fruit extract on wound healing in diabetic and non-diabetic rats.

ABSTRACT

AIM: This study assessed the effects of topical application of R. coriaria extract on the rate of wound closure. The rate of wound contraction was used to assess the wound healing efficacy of the R. coriaria fruit methanolic extract. METHODS: Using excision and burn model of wound repair in diabetic male Wistar rats. Also, hydroxyproline, collagen content, and proinflammatory and anti-inflammatory cytokines levels were determined in this study. RESULTS: During the early wound healing phase, interleukin 6 (IL-6) levels were found to be decreased by R. coriaria treatment and increased the level of interleukin 10 (IL-10). Increased wound contraction augmented with hydroxyproline and collagen content, supporting the early wound healing exhibited by R. coriaria. The epithelialization, neovascularization and enhanced hydroxyproline and collagen expression were strongly associated with the healing pattern. CONCLUSION: This study indicating that R. coriaria methanolic fruit extract has a potent wound healing capacity. And may be effective in the topical therapy of wound healing.