Mesenchymal stem cell-derived extracellular vesicles prevent glioma by blocking M2 polarization of macrophages through a miR-744-5p/TGFB1-dependent mechanism.

Liu, Ling; Cheng, Meixiong; Zhang, Tian; Chen, Yong; Wu, Yaqiu; Wang, Qi

Liu, Ling; Cheng, Meixiong; Zhang, Tian; Chen, Yong; Wu, Yaqiu; Wang, Qi.

Afiliación

Liu L; Department of Neurosurgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Section 2, 1st Ring Road, Chengdu, 610072, Sichuan Province, People's Republic of China.
Cheng M; Department of Neurosurgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Section 2, 1st Ring Road, Chengdu, 610072, Sichuan Province, People's Republic of China.
Zhang T; Department of Neurosurgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Section 2, 1st Ring Road, Chengdu, 610072, Sichuan Province, People's Republic of China.
Chen Y; Department of Neurosurgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Section 2, 1st Ring Road, Chengdu, 610072, Sichuan Province, People's Republic of China.
Wu Y; Department of Neurosurgery Intensive Care Unit, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Section 2, 1st Ring Road, Chengdu, 610072, Sichuan Province, People's Republic of China. wuyaqiu@med.uestc.edu.cn.
Wang Q; Department of Neurosurgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Section 2, 1st Ring Road, Chengdu, 610072, Sichuan Province, People's Republic of China. wangqi@med.uestc.edu.cn.

Cell Biol Toxicol ; 38(4): 649-665, 2022 08.

Article en En | MEDLINE | ID: mdl-34978010

Asunto(s)

Vesículas Extracelulares; Glioma; Macrófagos; Células Madre Mesenquimatosas; MicroARNs; Factor de Crecimiento Transformador beta1; Animales; Glioma/metabolismo; Humanos; Macrófagos/metabolismo; Macrófagos/patología; Células Madre Mesenquimatosas/metabolismo; Ratones; MicroARNs/genética; Receptor Tipo I de Factor de Crecimiento Transformador beta/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo

Palabras clave

Glioma; Extracellular vesicles; microRNA-744-5p; TGFB1; TGFBR1; Mitogen-activated protein kinases; Macrophages; M2 polarization

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: MicroARNs / Factor de Crecimiento Transformador beta1 / Células Madre Mesenquimatosas / Vesículas Extracelulares / Glioma / Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Biol Toxicol Asunto de la revista: TOXICOLOGIA Año: 2022 Tipo del documento: Article

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