Your browser doesn't support javascript.
loading
Inflammation of Unknown Origin: Evaluation and Prognosis of 57 Cases.
Béra, Suzanne; Jamilloux, Yvan; Gerfaud-Valentin, Mathieu; Durupt, Stéphane; Nove-Josserand, Raphaèle; Lega, Jean-Christophe; Durieu, Isabelle; Hot, Arnaud; Sève, Pascal.
Afiliación
  • Béra S; Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, 69004 Lyon, France.
  • Jamilloux Y; Université Claude Bernard Lyon 1, 69000 Lyon, France.
  • Gerfaud-Valentin M; Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, 69004 Lyon, France.
  • Durupt S; Université Claude Bernard Lyon 1, 69000 Lyon, France.
  • Nove-Josserand R; Lyon Immunology Federation (LIFE), 69000 Lyon, France.
  • Lega JC; Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, 69004 Lyon, France.
  • Durieu I; Université Claude Bernard Lyon 1, 69000 Lyon, France.
  • Hot A; Université Claude Bernard Lyon 1, 69000 Lyon, France.
  • Sève P; Department of Internal Medicine, Hôpital Lyon-Sud, Hospices Civils de Lyon, 69310 Pierre-Benite, France.
J Clin Med ; 11(1)2021 Dec 22.
Article en En | MEDLINE | ID: mdl-35011773
ABSTRACT
(1)

Background:

there are few studies on the inflammation of unknown origin (IUO). We sought to determine the etiologies and prognosis of IUO, as well as the contribution of complementary examinations. (2)

Methods:

this retrospective study analyzed patients meeting the Vanderschueren's criteria in the Hospices Civils de Lyon from 2005 to 2020. (3)

Results:

a total of 57 patients (mean age 67 years; interquartile range 55-79) were included. Final diagnoses were made for 26 (46%) patients. Non-infectious inflammatory diseases were the most common diagnoses (13/26, 50%), followed by neoplasms (10/26, 38%; 8/10 hematological malignancies), infections (2/26, 8%), and miscellaneous causes (1/26, 4%). Moreover, 18-FDG-PET/CT was contributory in 12/42 cases. Anti-neutrophil cytoplasmic antibodies, serology, temporal biopsies, and bone marrow aspirates were contributory in 3/41, 1/57, 5/23, and 3/19 cases, respectively. At last follow-up (mean follow-up duration 48 months), 8/31 undiagnosed patients were cured (five received an empirical treatment), and 5/31 died (one death was related to the empirical treatment). (4)

Conclusion:

more than half of the IUO remained undiagnosed. Non-infectious inflammatory diseases and hematological malignancies were the most common etiologies. Moreover, 18-FDG-PET/CT had the highest diagnostic value. Most IUO without final diagnosis persisted. The role of empirical treatments remains to be explored.
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: J Clin Med Año: 2021 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Revista: J Clin Med Año: 2021 Tipo del documento: Article País de afiliación: Francia