Novel imidazo[1,2-a]pyridine derivatives induce apoptosis and cell cycle arrest in non-small cell lung cancer by activating NADPH oxidase mediated oxidative stress.

Bhavya, Kumari; Mantipally, Manohar; Roy, Soumyajit; Arora, Leena; Badavath, Vishnu Nayak; Gangireddy, Madhusudhanareddy; Dasgupta, Suman; Gundla, Rambabu; Pal, Durba

Bhavya, Kumari; Mantipally, Manohar; Roy, Soumyajit; Arora, Leena; Badavath, Vishnu Nayak; Gangireddy, Madhusudhanareddy; Dasgupta, Suman; Gundla, Rambabu; Pal, Durba.

Afiliación

Bhavya K; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.
Mantipally M; Department of Chemistry, School of Science, GITAM Deemed University, Hyderabad 502329, Telangana, India.
Roy S; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.
Arora L; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.
Badavath VN; Institute for Drug Research, The Hebrew University, Jerusalem 9112001, Israel; Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Gangireddy M; Department of Chemistry, School of Science, GITAM Deemed University, Hyderabad 502329, Telangana, India.
Dasgupta S; Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, Sonitpur 784028, Assam, India.
Gundla R; Department of Chemistry, School of Science, GITAM Deemed University, Hyderabad 502329, Telangana, India. Electronic address: rambabu.gundla@gitam.edu.
Pal D; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India. Electronic address: durba.pal@iitrpr.ac.in.

Life Sci ; 294: 120334, 2022 Apr 01.

Article en En | MEDLINE | ID: mdl-35065161

Asunto(s)

Adenocarcinoma del Pulmón/patología; Antineoplásicos/farmacología; Carcinoma de Pulmón de Células no Pequeñas/patología; Puntos de Control del Ciclo Celular; Neoplasias Pulmonares/patología; Estrés Oxidativo; Piridinas/farmacología; Adenocarcinoma del Pulmón/tratamiento farmacológico; Adenocarcinoma del Pulmón/metabolismo; Antineoplásicos/química; Apoptosis; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/metabolismo; Proliferación Celular; Humanos; Imidazoles/química; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/metabolismo; Potencial de la Membrana Mitocondrial; Piridinas/química; Especies Reactivas de Oxígeno/metabolismo; Células Tumorales Cultivadas; Proteínas Quinasas p38 Activadas por Mitógenos/genética; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

Apoptosis; Cell cycle arrest; Imidazo[1,2-a]pyridine; NADPH oxidase; Non-small cell lung cancer; Reactive oxygen species

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Carcinoma de Pulmón de Células no Pequeñas / Estrés Oxidativo / Puntos de Control del Ciclo Celular / Adenocarcinoma del Pulmón / Neoplasias Pulmonares / Antineoplásicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Life Sci Año: 2022 Tipo del documento: Article País de afiliación: India

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