The DOMINO web-server for active module identification analysis.
Bioinformatics
; 38(8): 2364-2366, 2022 04 12.
Article
en En
| MEDLINE
| ID: mdl-35139202
ABSTRACT
MOTIVATION Active module identification (AMI) is an essential step in many omics analyses. Such algorithms receive a gene network and a gene activity profile as input and report subnetworks that show significant over-representation of accrued activity signal ('active modules'). Such modules can point out key molecular processes in the analyzed biological conditions. RESULTS:
We recently introduced a novel AMI algorithm called DOMINO and demonstrated that it detects active modules that capture biological signals with markedly improved rate of empirical validation. Here, we provide an online server that executes DOMINO, making it more accessible and user-friendly. To help the interpretation of solutions, the server provides GO enrichment analysis, module visualizations and accessible output formats for customized downstream analysis. It also enables running DOMINO with various gene identifiers of different organisms. AVAILABILITY AND IMPLEMENTATION The server is available at http//domino.cs.tau.ac.il. Its codebase is available at https//github.com/Shamir-Lab.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Algoritmos
/
Programas Informáticos
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Israel