Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation.

Xie, Shan-Shan; Deng, Yan; Guo, Sheng-Lan; Li, Jia-Quan; Zhou, Ying-Chuan; Liao, Juan; Wu, Dan-Dan; Lan, Wei-Fang

Xie, Shan-Shan; Deng, Yan; Guo, Sheng-Lan; Li, Jia-Quan; Zhou, Ying-Chuan; Liao, Juan; Wu, Dan-Dan; Lan, Wei-Fang.

Afiliación

Xie SS; Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, 6 Shuang yong Road, Nanning, 530021, People's Republic of China.
Deng Y; Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, 6 Shuang yong Road, Nanning, 530021, People's Republic of China. 190662044@qq.com.
Guo SL; Department of Echocardiography of Cardiovascular Disease Institute, First Affiliated Hospital of Guangxi Medical University, 6 Shuang yong Road, Nanning, 530021, People's Republic of China. 190662044@qq.com.
Li JQ; Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, 6 Shuang yong Road, Nanning, 530021, People's Republic of China.
Zhou YC; Experimental Centre of Guangxi Medical University, Nanning, People's Republic of China.
Liao J; Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Wu DD; Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, 6 Shuang yong Road, Nanning, 530021, People's Republic of China.
Lan WF; Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, 6 Shuang yong Road, Nanning, 530021, People's Republic of China.

Sci Rep ; 12(1): 3056, 2022 02 23.

Article en En | MEDLINE | ID: mdl-35197507

Asunto(s)

Células Endoteliales/metabolismo; Ferroptosis/efectos de los fármacos; Hipertensión Pulmonar/metabolismo; Inflamasomas/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Animales; Toxinas Bacterianas/metabolismo; Células Cultivadas; Ciclohexilaminas/farmacología; Regulación hacia Abajo/efectos de los fármacos; Ferroptosis/genética; Proteína HMGB1/metabolismo; Ventrículos Cardíacos/diagnóstico por imagen; Ventrículos Cardíacos/efectos de los fármacos; Ventrículos Cardíacos/patología; Hemodinámica/efectos de los fármacos; Hipertensión Pulmonar/inducido químicamente; Hipertensión Pulmonar/patología; Inflamación/metabolismo; Pulmón/irrigación sanguínea; Pulmón/efectos de los fármacos; Macrófagos/metabolismo; Masculino; Monocrotalina/toxicidad; Fenilendiaminas/farmacología; Ratas Sprague-Dawley; Receptor Toll-Like 4/metabolismo; Regulación hacia Arriba/efectos de los fármacos

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Endoteliales / Inflamasomas / Proteína con Dominio Pirina 3 de la Familia NLR / Ferroptosis / Hipertensión Pulmonar Límite: Animals Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article

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