Pentosan polysulfate ameliorates fibrosis and inflammation markers in SV40 MES13 cells by suppressing activation of PI3K/AKT pathway via miR-446a-3p.

Xiao, Liangxiang; Chen, Anqun; Gao, Qing; Xu, Bo; Guo, Xiaodan; Guan, Tianjun

Xiao, Liangxiang; Chen, Anqun; Gao, Qing; Xu, Bo; Guo, Xiaodan; Guan, Tianjun.

Afiliación

Xiao L; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Chen A; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Gao Q; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Xu B; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Guo X; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Guan T; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China. tianjunguan@aliyun.com.

BMC Nephrol ; 23(1): 105, 2022 03 15.

Article en En | MEDLINE | ID: mdl-35291969

Asunto(s)

Nefropatías Diabéticas; MicroARNs; Animales; Biomarcadores; Nefropatías Diabéticas/patología; Fibrosis; Inflamación/complicaciones; Inflamación/tratamiento farmacológico; Interleucina-6; Ratones; MicroARNs/genética; Poliéster Pentosan Sulfúrico/farmacología; Fosfatidilinositol 3-Quinasa; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Advanced glycation end products; Diabetic nephrology; Pentosan polysulphate sodium; Renal fibrosis; microRNA

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: MicroARNs / Nefropatías Diabéticas Límite: Animals Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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