Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3 receptor agonist.

Ochi, Motoki; Kinoshita, Kohnosuke; Yamaguchi, Jun-Ichi; Endo, Hiromi

Ochi, Motoki; Kinoshita, Kohnosuke; Yamaguchi, Jun-Ichi; Endo, Hiromi.

Afiliación

Ochi M; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Kinoshita K; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Yamaguchi JI; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Endo H; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories, Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.

Xenobiotica ; 52(2): 119-128, 2022 Feb.

Article en En | MEDLINE | ID: mdl-35296225

Asunto(s)

Profármacos; Compuestos Bicíclicos con Puentes; Ácidos Dicarboxílicos; Ésteres/metabolismo; Ácido Glutámico; Humanos; Modelos Biológicos; Profármacos/farmacocinética; Estudios Retrospectivos

Palabras clave

MGS0008; MGS0274; PBPK model; TS-134; carboxylesterase; ester prodrug; passive diffusion

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Profármacos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Xenobiotica Año: 2022 Tipo del documento: Article País de afiliación: Japón

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