Unique molecular features and cellular responses differentiate two populations of motor cortical layer 5b neurons in a preclinical model of ALS.

Moya, Maria V; Kim, Rachel D; Rao, Meghana N; Cotto, Bianca A; Pickett, Sarah B; Sferrazza, Caroline E; Heintz, Nathaniel; Schmidt, Eric F

Moya, Maria V; Kim, Rachel D; Rao, Meghana N; Cotto, Bianca A; Pickett, Sarah B; Sferrazza, Caroline E; Heintz, Nathaniel; Schmidt, Eric F.

Afiliación

Moya MV; Laboratory of Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 260, New York, NY 10065, USA.
Kim RD; Laboratory of Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 260, New York, NY 10065, USA.
Rao MN; Laboratory of Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 260, New York, NY 10065, USA.
Cotto BA; Laboratory of Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 260, New York, NY 10065, USA.
Pickett SB; Laboratory of Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 260, New York, NY 10065, USA.
Sferrazza CE; Laboratory of Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 260, New York, NY 10065, USA.
Heintz N; Laboratory of Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 260, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Schmidt EF; Laboratory of Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 260, New York, NY 10065, USA. Electronic address: eschmidt@rockefeller.edu.

Cell Rep ; 38(12): 110556, 2022 03 22.

Article en En | MEDLINE | ID: mdl-35320722

Asunto(s)

Esclerosis Amiotrófica Lateral; Corteza Motora; Enfermedades Neurodegenerativas; Esclerosis Amiotrófica Lateral/metabolismo; Animales; Modelos Animales de Enfermedad; Ratones; Ratones Transgénicos; Corteza Motora/metabolismo; Neuronas Motoras/metabolismo; Enfermedades Neurodegenerativas/metabolismo; Superóxido Dismutasa/metabolismo; Superóxido Dismutasa-1/genética; Superóxido Dismutasa-1/metabolismo

Palabras clave

ALS; CP: Neuroscience; G93A; RNA-seq; SOD1; TRAP; corticopontine; corticospinal; motor cortex

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Esclerosis Amiotrófica Lateral / Corteza Motora Límite: Animals Idioma: En Revista: Cell Rep Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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