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Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women.
Bachmann, Dario; Roman, Zachary J; Buchmann, Andreas; Zuber, Isabelle; Studer, Sandro; Saake, Antje; Rauen, Katrin; Gruber, Esmeralda; Nitsch, Roger M; Hock, Christoph; Gietl, Anton F; Treyer, Valerie.
Afiliación
  • Bachmann D; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
  • Roman ZJ; Department of Psychology, Psychological Methods, Evaluation, and Statistics, University of Zurich, Zurich, Switzerland.
  • Buchmann A; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
  • Zuber I; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
  • Studer S; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
  • Saake A; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
  • Rauen K; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
  • Gruber E; Department of Geriatric Psychiatry, Psychiatric Hospital Zurich, Zurich, Switzerland.
  • Nitsch RM; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
  • Hock C; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
  • Gietl AF; Neurimmune, Zurich, Switzerland.
  • Treyer V; Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Ann Neurol ; 92(3): 451-463, 2022 09.
Article en En | MEDLINE | ID: mdl-35598071
OBJECTIVE: Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed inter-relationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors with brain amyloid burden and cognition. METHODS: We studied 178 cognitively normal individuals (women, 49%; 65.0 [7.6] years) and 54 individuals with mild cognitive impairment (women, 35%; 71.3 [8.3] years) enrolled in a prospective study of volunteers who completed 18 F-Flutemetamol amyloid positron emission tomography. Using structural equation modeling, we examined associations between latent constructs representing metabolic/vascular risk, physical activity, and cognitive activity with global amyloid burden and cognitive performance. Furthermore, we investigated the influence of sex in this model. RESULTS: Overall, higher cognitive activity was associated with better cognitive performance and higher physical activity was associated with lower amyloid burden. The latter association was weakened to a nonsignificant level after excluding multivariate outliers. Examination of the moderating effect of sex in the model revealed an inverse association of metabolic/vascular risk with cognition in men, whereas in women metabolic/vascular risk trended toward increased amyloid burden. Furthermore, a significant inverse association between physical activity and amyloid burden was found only in men. Inheritance of an APOE4 allele was associated with higher amyloid burden only in women. INTERPRETATION: Sex modifies effects of certain lifestyle-related factors on amyloid burden and cognition. Notably, our results suggest that the negative impact of metabolic/vascular risk influences the risk of cognitive decline and Alzheimer's disease through distinct paths in women and men. ANN NEUROL 2022;92:451-463.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Año: 2022 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Año: 2022 Tipo del documento: Article País de afiliación: Suiza