Oridonin suppresses particulate-induced NLRP3-independent IL-1&#945; release to prevent crystallopathy in the lung.

Ikoma, Kenta; Takahama, Michihiro; Kimishima, Atsushi; Pan, Yixi; Taura, Manabu; Nakayama, Akiyoshi; Arai, Masayoshi; Takemura, Naoki; Saitoh, Tatsuya

Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung.

Ikoma, Kenta; Takahama, Michihiro; Kimishima, Atsushi; Pan, Yixi; Taura, Manabu; Nakayama, Akiyoshi; Arai, Masayoshi; Takemura, Naoki; Saitoh, Tatsuya.

Afiliación

Ikoma K; Laboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Takahama M; Division of Inflammation Biology, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
Kimishima A; Pritzker School of Molecular Engineering, the University of Chicago, Chicago, IL, USA.
Pan Y; Laboratory of Natural Products for Drug Discovery, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Taura M; Laboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Nakayama A; Laboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Arai M; Division of Inflammation Biology, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
Takemura N; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
Saitoh T; Laboratory of Natural Products for Drug Discovery, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

Int Immunol ; 34(10): 493-504, 2022 09 09.

Article en En | MEDLINE | ID: mdl-35639943

Asunto(s)

Diterpenos de Tipo Kaurano; Interleucina-1beta; Pulmón; Proteína con Dominio Pirina 3 de la Familia NLR; Material Particulado; Neumonía; Animales; Diterpenos de Tipo Kaurano/farmacología; Diterpenos de Tipo Kaurano/uso terapéutico; Humanos; Inflamasomas/efectos de los fármacos; Inflamasomas/inmunología; Interleucina-1beta/antagonistas & inhibidores; Interleucina-1beta/metabolismo; Pulmón/efectos de los fármacos; Pulmón/inmunología; Ratones; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Material Particulado/toxicidad; Neumonía/inducido químicamente; Neumonía/tratamiento farmacológico; Neumonía/inmunología

Palabras clave

cytokine; inflammation; innate immunity; organelle; silicosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neumonía / Diterpenos de Tipo Kaurano / Interleucina-1beta / Material Particulado / Proteína con Dominio Pirina 3 de la Familia NLR / Pulmón Límite: Animals / Humans Idioma: En Revista: Int Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón

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