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The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction phenotype in human-induced pluripotent stem cell-derived cardiomyocytes.
Calloe, Kirstine; Geryk, Michelle; Freude, Kristine; Treat, Jacqueline A; Vold, Victoria A; Frederiksen, Henriette Reventlow S; Broendberg, Anders Krogh; Frederiksen, Tanja Charlotte; Jensen, Henrik K; Cordeiro, Jonathan M.
Afiliación
  • Calloe K; Section for Pathobiological Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Dyrlaegevej 100 DK-1870 Frederiksberg, Denmark.
  • Geryk M; Section for Pathobiological Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Dyrlaegevej 100 DK-1870 Frederiksberg, Denmark.
  • Freude K; Section for Pathobiological Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Dyrlaegevej 100 DK-1870 Frederiksberg, Denmark.
  • Treat JA; Department of Experimental Cardiology, Masonic Medical Research Institute, 2150 Bleecker Street, Utica, NY 13501, USA.
  • Vold VA; Section for Pathobiological Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Dyrlaegevej 100 DK-1870 Frederiksberg, Denmark.
  • Frederiksen HRS; Section for Pathobiological Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Dyrlaegevej 100 DK-1870 Frederiksberg, Denmark.
  • Broendberg AK; Department of Cardiology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark.
  • Frederiksen TC; Department of Cardiology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark.
  • Jensen HK; Department of Clinical Medicine, Aarhus University, DK-8200 Aarhus N, Denmark.
  • Cordeiro JM; Department of Cardiology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark.
Europace ; 24(12): 2015-2027, 2022 Dec 09.
Article en En | MEDLINE | ID: mdl-35726875
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Miocitos Cardíacos / Células Madre Pluripotentes Inducidas / Canal de Sodio Activado por Voltaje NAV1.5 Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Europace Asunto de la revista: CARDIOLOGIA / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Miocitos Cardíacos / Células Madre Pluripotentes Inducidas / Canal de Sodio Activado por Voltaje NAV1.5 Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Europace Asunto de la revista: CARDIOLOGIA / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca