Early and Aggressive Treatment May Modify Anti-Hu Associated Encephalitis Prognosis.
Neuropediatrics
; 54(1): 64-67, 2023 02.
Article
en En
| MEDLINE
| ID: mdl-35817357
ABSTRACT
Anti-Hu encephalitis is a paraneoplastic syndrome in adults. In children, rare cases of anti-Hu encephalitis were reported mostly without underlying tumors and clinical outcome are usually severe. Here, we describe a 4-year-old girl who developed cerebellar syndrome with abnormal behavior. The brain magnetic resonance imaging showed several T2/fluid-attenuated inversion recovery bilateral brain lesions and autoimmune assessment showed positive anti-Hu antibodies. Computed tomography scan revealed ganglioneuroblastoma which was surgically removed 3 months after onset. Aggressive immunotherapy including dexamethasone, rituximab, and intravenous immunoglobulins were used and a marked neurological improvement soon after 9 months of onset was observed with the child being able to go back to school. The short delay between diagnosis and start of aggressive immunotherapy demonstrate the paramount importance of early diagnosis and early specific therapy after onset of symptoms.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Encefalitis
/
Enfermedades del Sistema Nervioso
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adult
/
Child
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Child, preschool
/
Female
/
Humans
Idioma:
En
Revista:
Neuropediatrics
Año:
2023
Tipo del documento:
Article
País de afiliación:
Francia