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Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo.
Ding, Xiaokai; Sharko, Amanda C; McDermott, Martina S J; Schools, Gary P; Chumanevich, Alexander; Ji, Hao; Li, Jing; Zhang, Li; Mack, Zachary T; Sikirzhytski, Vitali; Shtutman, Michael; Ivers, Laura; O'Donovan, Norma; Crown, John; Gyorffy, Balázs; Chen, Mengqian; Roninson, Igor B; Broude, Eugenia V.
Afiliación
  • Ding X; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Sharko AC; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • McDermott MSJ; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Schools GP; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Chumanevich A; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Ji H; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Li J; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Zhang L; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Mack ZT; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Sikirzhytski V; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Shtutman M; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Ivers L; National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.
  • O'Donovan N; National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.
  • Crown J; National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.
  • Gyorffy B; Department of Bioinformatics, Semmelweis University, Budapest, H-1085, Hungary.
  • Chen M; Oncology Biomarker Research Group, Research Center for Natural Sciences, H-1117, Budapest, Hungary.
  • Roninson IB; Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, 715 Sumter St., Columbia, SC, 29208.
  • Broude EV; Senex Biotechnology, Inc., 715 Sumter St., Columbia, SC, 29208.
Proc Natl Acad Sci U S A ; 119(32): e2201073119, 2022 08 09.
Article en En | MEDLINE | ID: mdl-35914167
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Quinasas Ciclina-Dependientes / Resistencia a Antineoplásicos / Inhibidores de Proteínas Quinasas / Quinasa 8 Dependiente de Ciclina Límite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Quinasas Ciclina-Dependientes / Resistencia a Antineoplásicos / Inhibidores de Proteínas Quinasas / Quinasa 8 Dependiente de Ciclina Límite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article