Therapeutic intervention of glioma with the novel antineoplastic agent T11TS: the story so far.

Glioma is a fatal brain tumor, and conventional treatments with surgery, radiotherapy, and chemotherapy often cause cancer recurrence. Therefore, newer strategies of treatment are being developed. In the authors' laboratory, a novel molecular approach with the biomolecule T11TS has been successfully applied in the eradication of glioma in an experimental rat model and on human samples. T11TS ameliorates glioma by various means, including immune augmentation and cytokine modulation; causes glioma cell death (apoptotic); halts the glioma cell cycle; and retards glioma blood vessel growth (antiangiogenic). T11TS is nontoxic. The author's study points to novel glioma therapy.