Opium use and risk of lung cancer: A multicenter case-control study in Iran.
Int J Cancer
; 152(2): 203-213, 2023 01 15.
Article
en En
| MEDLINE
| ID: mdl-36043555
ABSTRACT
Opium use was recently classified as a human carcinogen for lung cancer by the International Agency for Research on Cancer. We conducted a large, multicenter case-control study evaluating the association between opium use and the risk of lung cancer. We recruited 627 cases and 3477 controls from May 2017 to July 2020. We used unconditional logistic regression analyses to estimate the odds ratios (OR) and 95% confidence intervals (CI) and measured the association between opium use and the risk of lung cancer. The ORs were adjusted for the residential place, age, gender, socioeconomic status, cigarettes, and water pipe smoking. We found a 3.6-fold risk of lung cancer for regular opium users compared to never users (95% CI 2.9, 4.6). There was a strong dose-response association between a cumulative count of opium use and lung cancer risk. The OR for regular opium use was higher for small cell carcinoma than in other histology (8.3, 95% CI 4.8, 14.4). The OR of developing lung cancer among opium users was higher in females (7.4, 95% CI 3.8, 14.5) than in males (3.3, 95% CI 2.6, 4.2). The OR for users of both opium and tobacco was 13.4 (95% CI 10.2, 17.7) compared to nonusers of anything. The risk of developing lung cancer is higher in regular opium users, and these results strengthen the conclusions on the carcinogenicity of opium. The association is stronger for small cell carcinoma cases than in other histology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Pequeñas
/
Carcinoma Pulmonar de Células Pequeñas
/
Adicción al Opio
/
Neoplasias Pulmonares
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Int J Cancer
Año:
2023
Tipo del documento:
Article
País de afiliación:
Irán