Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues.
Epigenomics
; 14(18): 1105-1124, 2022 09.
Article
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| MEDLINE
| ID: mdl-36200237
ABSTRACT
Aims & methods:
The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used.Results:
nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas â¼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle.Conclusion:
The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Gemelos Monocigóticos
/
Metilación de ADN
Límite:
Humans
Idioma:
En
Revista:
Epigenomics
Año:
2022
Tipo del documento:
Article
País de afiliación:
Finlandia