Stem cell-based multi-tissue platforms to model human autoimmune diabetes.

Leavens, Karla F; Alvarez-Dominguez, Juan R; Vo, Linda T; Russ, Holger A; Parent, Audrey V

Leavens, Karla F; Alvarez-Dominguez, Juan R; Vo, Linda T; Russ, Holger A; Parent, Audrey V.

Afiliación

Leavens KF; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania and Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alvarez-Dominguez JR; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Vo LT; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Russ HA; Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Parent AV; Diabetes Center, University of California San Francisco, San Francisco, CA, USA. Electronic address: audrey.parent@ucsf.edu.

Mol Metab ; 66: 101610, 2022 12.

Article en En | MEDLINE | ID: mdl-36209784

Asunto(s)

Diabetes Mellitus Tipo 1; Células Madre Pluripotentes Inducidas; Células Secretoras de Insulina; Células Madre Pluripotentes; Humanos; Diabetes Mellitus Tipo 1/metabolismo; Células Madre Pluripotentes/metabolismo; Células Secretoras de Insulina/metabolismo; Células Madre Pluripotentes Inducidas/metabolismo; Diferenciación Celular

Palabras clave

Autoimmunity; Direct differentiation; Disease modeling; Genome engineering; Pancreatic ß cells; Pluripotent stem cells; T cells; Thymus; Type 1 diabetes

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Pluripotentes / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina / Células Madre Pluripotentes Inducidas Límite: Humans Idioma: En Revista: Mol Metab Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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