Principles and functions of metabolic compartmentalization.
Nat Metab
; 4(10): 1232-1244, 2022 10.
Article
en En
| MEDLINE
| ID: mdl-36266543
ABSTRACT
Metabolism has historically been studied at the levels of whole cells, whole tissues and whole organisms. As a result, our understanding of how compartmentalization-the spatial and temporal separation of pathways and components-shapes organismal metabolism remains limited. At its essence, metabolic compartmentalization fulfils three important functions or 'pillars' establishing unique chemical environments, providing protection from reactive metabolites and enabling the regulation of metabolic pathways. However, how these pillars are established, regulated and maintained at both the cellular and systemic levels remains unclear. Here we discuss how the three pillars are established, maintained and regulated within the cell and discuss the consequences of dysregulation of metabolic compartmentalization in human disease. Organelles are increasingly emerging as 'command-and-control centres' and the increased understanding of metabolic compartmentalization is revealing new aspects of metabolic homeostasis, with this knowledge being translated into therapies for the treatment of cancer and certain neurodegenerative diseases.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Orgánulos
/
Redes y Vías Metabólicas
Límite:
Humans
Idioma:
En
Revista:
Nat Metab
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos