Total synthesis of antiviral drug, nirmatrelvir (PF-07321332).

Shekhar, Chandra; Nasam, Rajesh; Paipuri, Siva Ramakrishna; Kumar, Prakash; Nayani, Kiranmai; Pabbaraja, Srihari; Mainkar, Prathama S; Chandrasekhar, Srivari

Shekhar, Chandra; Nasam, Rajesh; Paipuri, Siva Ramakrishna; Kumar, Prakash; Nayani, Kiranmai; Pabbaraja, Srihari; Mainkar, Prathama S; Chandrasekhar, Srivari.

Afiliación

Shekhar C; Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
Nasam R; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Paipuri SR; Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
Kumar P; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Nayani K; Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
Pabbaraja S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Mainkar PS; Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
Chandrasekhar S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.

Tetrahedron Chem ; 4: 100033, 2022 Dec.

Article en En | MEDLINE | ID: mdl-36276807

Palabras clave

Amino acid; Antiviral drug; Boc, tert-butyloxycarbonyl; COVID-19; Cyclopropanation; DMAP, 4-dimethylaminopyridine; DMP, DessMartin periodinane; FDA, Food and Drug Administration; HATU, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate; LiHMDS, lithium bis(trimethylsilyl)amide; MsCl, methanesulfonyl chloride; NMM, N-methylmorpholine; Peptide; Peptide coupling; Protein mimetic; SAR, structure activity relationship; SARS-CoV, severe acute respiratory syndrome coronavirus; TMSCl, trimethylsilyl chloride

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Tetrahedron Chem Año: 2022 Tipo del documento: Article País de afiliación: India

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