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The roles of rat medial prefrontal and orbitofrontal cortices in relapse to cocaine-seeking: A comparison across methods for identifying neurocircuits.
Mesa, Javier R; Wesson, Daniel W; Schwendt, Marek; Knackstedt, Lori A.
Afiliación
  • Mesa JR; Department of Psychology, University of Florida, 114 Psychology, 945 Center Dr., Gainesville, FL 32611, USA.
  • Wesson DW; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA.
  • Schwendt M; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA.
  • Knackstedt LA; Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA.
Addict Neurosci ; 42022 Dec.
Article en En | MEDLINE | ID: mdl-36277334
A large body of research supports the notion that regions of the rodent frontal cortex regulate reinstatement of cocaine seeking after cessation of intravenous cocaine self-administration. However, earlier studies identifying the roles of medial (mPFC) and orbital prefrontal cortices (OFC) in reinstatement relied on pharmacological inactivation methods, which indiscriminately inhibited cells within a target region. Here, we first review the anatomical borders and pathways of the rat mPFC and OFC. Next, we compare and contrast findings from more recent cocaine seeking and reinstatement studies that used chemogenetics, optogenetics, or advanced tracing to manipulate specific local cell types or input/output projections of the mPFC and OFC subregions. We found that these studies largely corroborated the roles for mPFC subregions as ascribed by pharmacological inactivation studies. Namely, the prelimbic cortex generally drives cocaine seeking behaviors while the infralimbic cortex is recruited to inhibit cocaine seeking by extinction training but may contribute to seeking after prolonged abstinence. While the OFC remains understudied, we suggest it should not be overlooked, and, as with prelimbic and infralimbic cortices, we identify specific pathways of interest for future studies.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Addict Neurosci Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Addict Neurosci Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos