Calreticulin surface presentation can promote quality control of hematopoietic stem cells.

Galluzzi, Lorenzo; Kroemer, Guido

Galluzzi, Lorenzo; Kroemer, Guido.

Afiliación

Galluzzi L; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. Electronic address: deadoc80@gmail.com.
Kroemer G; Centre de Recherche des Cordeliers, Equipe la Bellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France. Electronic address: kroemer@orange.fr.

Trends Immunol ; 43(12): 950-952, 2022 12.

Article en En | MEDLINE | ID: mdl-36307308

ABSTRACT

ABSTRACT

Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis.

Asunto(s)

Calreticulina; Hematopoyesis; Células Madre Hematopoyéticas; Animales; Ratones; Calreticulina/metabolismo; Pez Cebra

Palabras clave

autophagy; cancer immunosurveillance; hematopoiesis; immunogenic cell death; sterile inflammation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas / Calreticulina / Hematopoyesis Límite: Animals Idioma: En Revista: Trends Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article

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