Insulin Suppresses Ubiquitination via the Deubiquitinating Enzyme Ubiquitin-Specific Protease 14, Independent of Proteasome Activity in H4IIEC3 Hepatocytes.

Kamoshita, Kyoko; Ishii, Kiyo-Aki; Tahira, Yumiko; Kikuchi, Akihiro; Abuduwaili, Halimulati; Tajima-Shirasaki, Natsumi; Li, Qifang; Takayama, Hiroaki; Matsumoto, Kunio; Takamura, Toshinari

Kamoshita, Kyoko; Ishii, Kiyo-Aki; Tahira, Yumiko; Kikuchi, Akihiro; Abuduwaili, Halimulati; Tajima-Shirasaki, Natsumi; Li, Qifang; Takayama, Hiroaki; Matsumoto, Kunio; Takamura, Toshinari.

Afiliación

Kamoshita K; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H
Ishii KA; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H
Tahira Y; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H
Kikuchi A; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H
Abuduwaili H; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H
Tajima-Shirasaki N; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H
Li Q; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H
Takayama H; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H
Matsumoto K; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H
Takamura T; Department of Endocrinology and Metabolism, Graduate School of Medical Sciences (K.K., K.A.I., Y.T., A.K., H.A., N.T.S., Q.L., H.T., T.T.); Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences (K.A.I.); Life Sciences Division, Engineering and Technology Department (H

J Pharmacol Exp Ther ; 385(1): 5-16, 2023 04.

Article en En | MEDLINE | ID: mdl-36328485

Asunto(s)

Hepatocitos; Enfermedad del Hígado Graso no Alcohólico; Complejo de la Endopetidasa Proteasomal; Proteína 1 de Unión a los Elementos Reguladores de Esteroles; Humanos; Enzimas Desubicuitinizantes/genética; Enzimas Desubicuitinizantes/metabolismo; Diabetes Mellitus/genética; Diabetes Mellitus/metabolismo; Hepatocitos/efectos de los fármacos; Hepatocitos/metabolismo; Insulina/farmacología; Insulina/metabolismo; Enfermedad del Hígado Graso no Alcohólico/genética; Enfermedad del Hígado Graso no Alcohólico/metabolismo; Obesidad/genética; Obesidad/metabolismo; Complejo de la Endopetidasa Proteasomal/genética; Complejo de la Endopetidasa Proteasomal/metabolismo; Complejo de la Endopetidasa Proteasomal/farmacología; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/genética; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/metabolismo; Ubiquitina Tiolesterasa/genética; Ubiquitina Tiolesterasa/metabolismo; Proteasas Ubiquitina-Específicas/genética; Proteasas Ubiquitina-Específicas/metabolismo; Proteasas Ubiquitina-Específicas/farmacología; Proteínas Ubiquitinadas/genética; Proteínas Ubiquitinadas/metabolismo; Proteínas Ubiquitinadas/farmacología; Ubiquitinación; Ubiquitinas/genética; Ubiquitinas/metabolismo; Ubiquitinas/farmacología

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hepatocitos / Complejo de la Endopetidasa Proteasomal / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Enfermedad del Hígado Graso no Alcohólico Límite: Humans Idioma: En Revista: J Pharmacol Exp Ther Año: 2023 Tipo del documento: Article

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