Relationship between carotid intima-media thickness and periodontal disease in a Japanese urban population with and without hypertension: The Suita Study.
J Clin Periodontol
; 50(2): 265-275, 2023 02.
Article
en En
| MEDLINE
| ID: mdl-36330666
ABSTRACT
AIM:
To investigate the association between periodontal disease and atherosclerosis and to examine whether the association is modified by hypertension status. MATERIALS ANDMETHODS:
In this cross-sectional study, 1472 Japanese individuals aged 50-79 years who underwent a medical check-up, dental examination, and carotid ultrasonography were studied. Carotid atherosclerosis was expressed as the maximum and mean carotid intima-media thickness (max-IMT, mean-IMT) and the presence of stenosis (≥75%). Periodontal status was examined by the Community Periodontal Index (CPI, codes 0-4). The participants were divided into three groups according to the periodontal status (CPI0-2, CPI3, CPI4).RESULTS:
A positive correlation was found between mean-IMT and periodontal disease after adjustment for cardiovascular risk factors in the entire cohort (mean-IMT in hypertensives CPI0-2 0.848 mm, CPI3 0.857 mm, CPI4 0.877 mm; normotensives 0.782, 0.802, 0.826). In the entire cohort, the multivariable-adjusted odds ratio of stenosis based on mean-IMT significantly increased according to periodontal status in normotensives (odds ratio; CPI0-2 1, CPI3 1.39, CPI4 2.53; p-value for trend = .004) but showed only marginal significant increase in hypertensives (1, 1.15, 1.55; p-value for trend = .063). No significant relationships were observed for max-IMT in all analyses.CONCLUSION:
We observed an association between periodontal disease and atherosclerosis in normotensive and hypertensive participants.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Periodontales
/
Enfermedades de las Arterias Carótidas
/
Aterosclerosis
/
Hipertensión
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J Clin Periodontol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Japón