Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity.

Dunker, Calvin; Imberg, Lukas; Siutkina, Alena I; Erbacher, Catharina; Daniliuc, Constantin G; Karst, Uwe; Kalinin, Dmitrii V

Dunker, Calvin; Imberg, Lukas; Siutkina, Alena I; Erbacher, Catharina; Daniliuc, Constantin G; Karst, Uwe; Kalinin, Dmitrii V.

Afiliación

Dunker C; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.
Imberg L; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.
Siutkina AI; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.
Erbacher C; Institute of Inorganic and Analytical Chemistry, University of Münster, 48149 Münster, Germany.
Daniliuc CG; Institute for Organic Chemistry, University of Münster, 48149 Münster, Germany.
Karst U; Institute of Inorganic and Analytical Chemistry, University of Münster, 48149 Münster, Germany.
Kalinin DV; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.

Pharmaceuticals (Basel) ; 15(11)2022 Oct 28.

Article en En | MEDLINE | ID: mdl-36355511

Palabras clave

Ullmann reaction; anticoagulants; covalent inhibitor; dabigatran; pyrazole; pyrazolo[1,5-a]quinazolin-5(4H)-ones; pyrazolo[5,1-b]quinazolin-9(4H)-ones; thrombin; thrombosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Alemania

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