Association of sex-specific donor skeletal muscle index with surgical outcomes in living donor liver transplantation recipients.
Liver Int
; 43(3): 684-694, 2023 03.
Article
en En
| MEDLINE
| ID: mdl-36377561
ABSTRACT
BACKGROUND:
A recent study reported a correlation between the muscle mass of male donors and graft failure in living donor liver transplantation (LDLT) recipients. We investigated the association of sex-specific donor skeletal muscle index (SMI) with mortality and graft failure in LDLT recipients.METHODS:
We retrospectively analysed 2750 sets of donors and recipients between January 2008 and January 2018. The recipient outcomes were analysed by dividing the data according to donor sex. Cox regression analyses were performed to evaluate the association between donor SMI by sex and 1-year mortality and graft failure in recipients.RESULTS:
In the male donor group, robust donor (increased SMI) was significantly associated with higher risks for mortality (hazard ratio [HR] 1.03, 95% confidence interval [CI] 1.00-1.06, p = .023) and graft failure (HR 1.04, 95% CI 1.01-1.06, p = .007) at 1 year. In the female donor group, the robust donor was significantly associated with lower risks for mortality (HR 0.92, 95% CI 0.87-0.97, p = .003) and graft failure (HR 0.95, 95% CI 0.90-1.00, p = .032) at 1 year.CONCLUSIONS:
Donor SMI was associated with surgical outcomes in recipients. Robust male and female donors were a significant negative and protective factor for grafts respectively.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Hígado
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Liver Int
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2023
Tipo del documento:
Article