Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities.
J Nat Prod
; 86(1): 209-221, 2023 01 27.
Article
en En
| MEDLINE
| ID: mdl-36583957
ABSTRACT
Continued efforts to expand the structural diversity of dichapetalins and explore further the cytotoxic structure-activity relationships have led to the isolation of 17 undescribed analogues, dichapelonins A-Q (1-17), and three known compounds (18-20) from the twigs of Dichapetalum longipetalum. Compounds 1-17 comprise five compound classes as classified by varied C6-C2 conjugates at the A ring of the 13,30-cyclodammarane skeleton, and their structures were determined by spectroscopic data analysis, experimental electronic circular dichroism measurements, and X-ray crystallography. Biological tests revealed compounds 1-7 with a phenyl-butadiene appendage to be the most potent cytotoxic compound type of those evaluated.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antineoplásicos
Idioma:
En
Revista:
J Nat Prod
Año:
2023
Tipo del documento:
Article