SLiM-binding pockets: an attractive target for broad-spectrum antivirals.
Trends Biochem Sci
; 48(5): 420-427, 2023 05.
Article
en En
| MEDLINE
| ID: mdl-36623987
ABSTRACT
Short linear motif (SLiM)-mediated interactions offer a unique strategy for viral intervention due to their compact interfaces, ease of convergent evolution, and key functional roles. Consequently, many viruses extensively mimic host SLiMs to hijack or deregulate cellular pathways and the same motif-binding pocket is often targeted by numerous unrelated viruses. A toolkit of therapeutics targeting commonly mimicked SLiMs could provide prophylactic and therapeutic broad-spectrum antivirals and vastly improve our ability to treat ongoing and future viral outbreaks. In this opinion article, we discuss the therapeutic relevance of SLiMs, advocating their suitability as targets for broad-spectrum antiviral inhibitors.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Secuencias de Aminoácidos
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2023
Tipo del documento:
Article
País de afiliación:
Suecia