Epicutaneous Immunotherapy with CBir1 Alleviates Intestinal Inflammation.

Chen, Xin; Elson, Charles O; Dunkin, David

Chen, Xin; Elson, Charles O; Dunkin, David.

Afiliación

Chen X; Division of Pediatric Gastroenterology and the Mindich Child Health and Development Institute (MCHDI), The Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
Elson CO; Department of Medicine, Division of Gastroenterology and Hepatology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Dunkin D; Division of Pediatric Gastroenterology and the Mindich Child Health and Development Institute (MCHDI), The Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.

Inflamm Bowel Dis ; 29(5): 798-807, 2023 05 02.

Article en En | MEDLINE | ID: mdl-36651798

Epicutaneous immunotherapy with a CBir1 multi-epitope peptide, the dominant flagellin for both murine and human, can induce Tregs that migrate to intestines and suppress inflammation in mice with CBir1 or A4Fla2-positive bacterial colonization.

Asunto(s)

Colitis; Enfermedad de Crohn; Inmunoterapia; Animales; Ratones; Ovalbúmina; Colitis/terapia; Ratones Endogámicos C57BL; Flagelina; Enfermedad de Crohn/terapia

Palabras clave

CBir1; colitis; epicutaneous immunotherapy; flagellin; tolerance

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Crohn / Colitis / Inmunoterapia Límite: Animals Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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