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Multi-timepoint imaging with PSMA-targeted [18F]F-Florastamin PET/CT: lesion detection and comparison to conventional imaging.
Sheikhbahaei, Sara; Bello Martinez, Ricardo; Markowski, Mark C; Eisenberger, Mario A; Pienta, Kenneth J; Reyes, Diane; Brosnan, Mary Katherine; Spiro, Ergi; AbdAllah, Rehab; Holt, Daniel P; Dannals, Robert F; Werner, Rudolf A; Pomper, Martin G; Gorin, Michael A; Solnes, Lilja B; Rowe, Steven P.
Afiliación
  • Sheikhbahaei S; The Russell H. Morgan, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St. JHOC Room 3233, Baltimore, MD, 21287, USA. ssheikh6@jhmi.edu.
  • Bello Martinez R; The Russell H. Morgan, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St. JHOC Room 3233, Baltimore, MD, 21287, USA.
  • Markowski MC; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Eisenberger MA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Pienta KJ; The Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Reyes D; The Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Brosnan MK; The Russell H. Morgan, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St. JHOC Room 3233, Baltimore, MD, 21287, USA.
  • Spiro E; The Russell H. Morgan, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St. JHOC Room 3233, Baltimore, MD, 21287, USA.
  • AbdAllah R; The Russell H. Morgan, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St. JHOC Room 3233, Baltimore, MD, 21287, USA.
  • Holt DP; The Russell H. Morgan, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St. JHOC Room 3233, Baltimore, MD, 21287, USA.
  • Dannals RF; The Russell H. Morgan, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St. JHOC Room 3233, Baltimore, MD, 21287, USA.
  • Werner RA; The Russell H. Morgan, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St. JHOC Room 3233, Baltimore, MD, 21287, USA.
  • Pomper MG; Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
  • Gorin MA; The Russell H. Morgan, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St. JHOC Room 3233, Baltimore, MD, 21287, USA.
  • Solnes LB; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Rowe SP; The Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ann Nucl Med ; 37(4): 246-254, 2023 Apr.
Article en En | MEDLINE | ID: mdl-36857019
OBJECTIVE: The aims of this study were to investigate the utility of [18F]F-Florastamin, a novel prostate-specific membrane antigen (PSMA)-targeted PET radiotracer with facile radiochemistry, relative to the conventional imaging for the detection of sties of disease and evaluate the effect of multi-timepoint imaging with [18F]F-Florastamin PET on lesion detectability. METHODS: Eight prostate cancer patients with known or suspected recurrence who underwent [18F]F-Florastamin PET/CT at 1-h and 2-h imaging time-points were included in this prospective pilot study. [18F]F-Florastamin PET images were interpreted visually and quantitatively at both time points and compared with CIM. RESULTS: [18F]F-Florastamin PET was superior to CT in the detection of active osseous metastases and small-sized metastatic lymph nodes that do not fall under the anatomic imaging size criteria for metastasis. Multi-timepoint imaging showed a significant reduction in the blood pool, bone marrow and muscular uptake, and increase in liver uptake over time. There is a significant improvement in tumor-to-background ratio (TBR) at the 2-h imaging time-point (P = 0.04). The mean percentage change in TBR at 2-h was 21% (SD = 0.31). CONCLUSIONS: [18F]F-Florastamin is a promising new radioligand for PSMA-targeted PET with suitable lesion detectability and high TBR at both time points.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Neoplasias Óseas Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Humans / Male Idioma: En Revista: Ann Nucl Med Asunto de la revista: MEDICINA NUCLEAR Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Neoplasias Óseas Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Humans / Male Idioma: En Revista: Ann Nucl Med Asunto de la revista: MEDICINA NUCLEAR Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos