Defining incidence and complications of fibrolamellar liver cancer through tiered computational analysis of clinical data.
NPJ Precis Oncol
; 7(1): 29, 2023 Mar 23.
Article
en En
| MEDLINE
| ID: mdl-36959495
ABSTRACT
The incidence and biochemical consequences of rare tumor subtypes are often hard to study. Fibrolamellar liver cancer (FLC) is a rare malignancy affecting adolescents and young adults. To better characterize the incidence and biochemical consequences of this disease, we combined a comprehensive analysis of the electronic medical record and national payer data and found that FLC incidence is likely five to eight times higher than previous estimates. By employing unsupervised learning on clinical laboratory data from patients with hyperammonemia, we find that FLC-associated hyperammonemia mirrors metabolic dysregulation in urea cycle disorders. Our findings demonstrate that advanced computational analysis of rich clinical datasets can provide key clinical and biochemical insights into rare cancers.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Incidence_studies
/
Risk_factors_studies
Idioma:
En
Revista:
NPJ Precis Oncol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos