Orthostatic hypertension and major adverse events: a systematic review and meta-analysis.
Eur J Prev Cardiol
; 30(10): 1028-1038, 2023 08 01.
Article
en En
| MEDLINE
| ID: mdl-37202364
Orthostatic hypertension (OHT) is defined as an arbitrary rise in upper (systolic) and/or lower (diastolic) blood pressure readings on standing. We performed a thorough literature search and combined the evidence of impact of OHT on future adverse events, including death, heart attack, heart failure, stroke, falls, and impaired cognition. We found the following:Twenty studies that investigated the association between OHT and future adverse events. Of these, 13 were eligible to be included in the combined evidence (meta-analysis). This formed a total sample of 61 669 participants (47.3% women), of which 55 456 (47.3% women) were included in the meta-analysis.Systolic OHT (SOHT) was associated with a significant 21% increased risk for death from any cause, a 39% greater risk of death due to heart and blood vessel disease and near doubled odds of stroke or brain vessel disease. Furthermore, three of four studies found a significant association between SOHT and impaired cognition. Diastolic OHT was not found to be associated with these outcomes. The lack of association with other outcomes investigated may be due to weak evidence.Eleven studies were of good quality, eight fair, and one poor. Differences in study design, study criteria, and study populations mean that the results need interpreting with caution. Future robust studies can build on this evidence to assess if treatment to reduce OHT would improve future outcomes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
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Trastornos Cerebrovasculares
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Accidente Cerebrovascular
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Hipertensión
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
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Systematic_reviews
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Eur J Prev Cardiol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Reino Unido