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Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
Park, Se-Hyung; Helsley, Robert N; Fadhul, Taghreed; Willoughby, Jennifer L S; Noetzli, Leila; Tu, Ho-Chou; Solheim, Marie H; Fujisaka, Shiho; Pan, Hui; Dreyfuss, Jonathan M; Bons, Joanna; Rose, Jacob; King, Christina D; Schilling, Birgit; Lusis, Aldons J; Pan, Calvin; Gupta, Manoj; Kulkarni, Rohit N; Fitzgerald, Kevin; Kern, Philip A; Divanovic, Senad; Kahn, C Ronald; Softic, Samir.
Afiliación
  • Park SH; Department of Pediatrics, Division of Pediatric Gastroenterology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
  • Helsley RN; Department of Pediatrics, Division of Pediatric Gastroenterology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
  • Fadhul T; Department of Pediatrics, Division of Pediatric Gastroenterology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
  • Willoughby JLS; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA.
  • Noetzli L; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA.
  • Tu HC; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA.
  • Solheim MH; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.
  • Fujisaka S; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; First Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.
  • Pan H; Bioinformatics and Biostatistics Core, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Dreyfuss JM; Bioinformatics and Biostatistics Core, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
  • Bons J; Proteomics and Aging Center, Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Rose J; Proteomics and Aging Center, Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • King CD; Proteomics and Aging Center, Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Schilling B; Proteomics and Aging Center, Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Lusis AJ; Department of Medicine/Division of Cardiology, Department of Human Genetics, A2-237 Center for the Health Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
  • Pan C; Department of Medicine/Division of Cardiology, Department of Human Genetics, A2-237 Center for the Health Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
  • Gupta M; Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA.
  • Kulkarni RN; Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA.
  • Fitzgerald K; Alnylam Pharmaceuticals Inc., Cambridge, MA 02142, USA.
  • Kern PA; Department of Medicine, Division of Endocrinology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
  • Divanovic S; Department of Pediatrics, University of Cincinnati College of Medicine, Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Kahn CR; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
  • Softic S; Department of Pediatrics, Division of Pediatric Gastroenterology, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Pharmacology and Nutritional
Metabolism ; 145: 155591, 2023 08.
Article en En | MEDLINE | ID: mdl-37230214
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Metabolism Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Metabolism Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos