Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains.
BMC Res Notes
; 16(1): 121, 2023 Jun 26.
Article
en En
| MEDLINE
| ID: mdl-37365644
ABSTRACT
OBJECTIVE:
Evaluate bovine viral diarrhea virus (BVDV) antigenicity by using virus neutralization titers (VNT) analyzed using the principal component analysis (PCA) from antisera generated against US-based vaccine strains against both US-origin field isolates and non-US-origin field isolates.RESULTS:
Data from both independent analyses demonstrated that several US-origin and non-US-origin BVDV field isolates appear to be antigenically divergent from the US-based vaccine strains. Results from the combined analysis provided greater insight into the antigenic diversity observed among BVDV isolates. Data from this study further support genetic assignment into BVDV subgenotypes, as well as strains within subgenotypes is not representative of antigenic relatedness. PCA highlights isolates that are antigenically divergent from members of the same species and subgenotype and conversely isolates that belong to different subgenotypes have similar antigenic characteristics when using antisera from US-based vaccine isolates.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diarrea Mucosa Bovina Viral
/
Vacunas
/
Virus de la Diarrea Viral Bovina
Límite:
Animals
Idioma:
En
Revista:
BMC Res Notes
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos