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Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.
Oh, Chang Joo; Kim, Min-Ji; Lee, Ji-Min; Kim, Dong Hun; Kim, Il-Young; Park, Sanghee; Kim, Yeongmin; Lee, Kyung-Bok; Lee, Sang-Hee; Lim, Chae Won; Kim, Myeongjin; Lee, Jung-Yi; Pagire, Haushabhau S; Pagire, Suvarna H; Bae, Myung Ae; Chanda, Dipanjan; Thoudam, Themis; Khang, Ah Reum; Harris, Robert A; Ahn, Jin Hee; Jeon, Jae-Han; Lee, In-Kyu.
Afiliación
  • Oh CJ; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
  • Kim MJ; Department of Internal Medicine, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
  • Lee JM; Cell & Matrix Research Institute, Kyungpook National University, Daegu, Republic of Korea.
  • Kim DH; Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu, Republic of Korea.
  • Kim IY; Department of Molecular Medicine, College of Medicine, Gachon University, Incheon, Republic of Korea; Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea.
  • Park S; Department of Exercise Rehabilitation, Gachon University, Incheon, Republic of Korea.
  • Kim Y; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Republic of Korea.
  • Lee KB; Center for Research Equipment (104-Dong), Korea Basic Science Institute, Ochang, Cheongju, Chungbuk, Republic of Korea.
  • Lee SH; Center for Research Equipment (104-Dong), Korea Basic Science Institute, Ochang, Cheongju, Chungbuk, Republic of Korea.
  • Lim CW; Department of Medicine, Graduate School, Daegu Catholic University, Gyeongsan, Gyeongbuk, Republic of Korea.
  • Kim M; Department of Medicine, Graduate School, Daegu Catholic University, Gyeongsan, Gyeongbuk, Republic of Korea.
  • Lee JY; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
  • Pagire HS; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
  • Pagire SH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
  • Bae MA; Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
  • Chanda D; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
  • Thoudam T; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
  • Khang AR; Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University College of Medicine, Yangsan, Republic of Korea.
  • Harris RA; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.
  • Ahn JH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. Electronic address: jhahn@gist.ac.kr.
  • Jeon JH; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea. Electronic address: je
  • Lee IK; Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Republic of Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea. Electronic address: leei@knu.a
Kidney Int ; 104(4): 724-739, 2023 10.
Article en En | MEDLINE | ID: mdl-37399974
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Daño por Reperfusión / Ácido Succínico Límite: Animals Idioma: En Revista: Kidney Int Año: 2023 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Daño por Reperfusión / Ácido Succínico Límite: Animals Idioma: En Revista: Kidney Int Año: 2023 Tipo del documento: Article