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A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis/chronic fatigue syndrome.
Briese, Thomas; Tokarz, Rafal; Bateman, Lucinda; Che, Xiaoyu; Guo, Cheng; Jain, Komal; Kapoor, Vishal; Levine, Susan; Hornig, Mady; Oleynik, Alexandra; Quan, Phenix-Lan; Wong, Wai H; Williams, Brent L; Vernon, Suzanne D; Klimas, Nancy G; Peterson, Daniel L; Montoya, Jose G; Ian Lipkin, Walter.
Afiliación
  • Briese T; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Tokarz R; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Bateman L; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Che X; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Guo C; Bateman Horne Center, Salt Lake City, Utah, USA.
  • Jain K; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Kapoor V; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Levine S; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Hornig M; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Oleynik A; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Quan PL; Levine Clinic, New York, New York, USA.
  • Wong WH; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Williams BL; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Vernon SD; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Klimas NG; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Peterson DL; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Montoya JG; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Ian Lipkin W; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
J Med Virol ; 95(8): e28993, 2023 08.
Article en En | MEDLINE | ID: mdl-37526404
ABSTRACT
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is estimated to affect 0.4%-2.5% of the global population. Most cases are unexplained; however, some patients describe an antecedent viral infection or response to antiviral medications. We report here a multicenter study for the presence of viral nucleic acid in blood, feces, and saliva of patients with ME/CFS using polymerase chain reaction and high-throughput sequencing. We found no consistent group-specific differences other than a lower prevalence of anelloviruses in cases compared to healthy controls. Our findings suggest that future investigations into viral infections in ME/CFS should focus on adaptive immune responses rather than surveillance for viral gene products.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome de Fatiga Crónica Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Humans Idioma: En Revista: J Med Virol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome de Fatiga Crónica Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Humans Idioma: En Revista: J Med Virol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos