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DNA methylation networks underlying mammalian traits.
Haghani, Amin; Li, Caesar Z; Robeck, Todd R; Zhang, Joshua; Lu, Ake T; Ablaeva, Julia; Acosta-Rodríguez, Victoria A; Adams, Danielle M; Alagaili, Abdulaziz N; Almunia, Javier; Aloysius, Ajoy; Amor, Nabil M S; Ardehali, Reza; Arneson, Adriana; Baker, C Scott; Banks, Gareth; Belov, Katherine; Bennett, Nigel C; Black, Peter; Blumstein, Daniel T; Bors, Eleanor K; Breeze, Charles E; Brooke, Robert T; Brown, Janine L; Carter, Gerald; Caulton, Alex; Cavin, Julie M; Chakrabarti, Lisa; Chatzistamou, Ioulia; Chavez, Andreas S; Chen, Hao; Cheng, Kaiyang; Chiavellini, Priscila; Choi, Oi-Wa; Clarke, Shannon; Cook, Joseph A; Cooper, Lisa N; Cossette, Marie-Laurence; Day, Joanna; DeYoung, Joseph; Dirocco, Stacy; Dold, Christopher; Dunnum, Jonathan L; Ehmke, Erin E; Emmons, Candice K; Emmrich, Stephan; Erbay, Ebru; Erlacher-Reid, Claire; Faulkes, Chris G; Fei, Zhe.
Afiliación
  • Haghani A; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Li CZ; Altos Labs, San Diego, CA, USA.
  • Robeck TR; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
  • Zhang J; Janssen Research & Development, Spring House, PA, USA.
  • Lu AT; Zoological Operations, SeaWorld Parks and Entertainment, Orlando, FL, USA.
  • Ablaeva J; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Acosta-Rodríguez VA; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Adams DM; Altos Labs, San Diego, CA, USA.
  • Alagaili AN; Department of Biology, University of Rochester, Rochester, NY, USA.
  • Almunia J; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Aloysius A; Department of Biology, University of Maryland, College Park, MD, USA.
  • Amor NMS; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
  • Ardehali R; Loro Parque Fundacion, Avenida Loro Parque, Puerto de la Cruz, Tenerife, Spain.
  • Arneson A; Department of Biology, University of Kentucky, Lexington, KY, USA.
  • Baker CS; Laboratory of Biodiversity, Parasitology, and Ecology, University of Tunis El Manar, Tunis, Tunisia.
  • Banks G; Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Belov K; Bioinformatics Interdepartmental Program, University of California, Los Angeles, CA, USA.
  • Bennett NC; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.
  • Black P; Marine Mammal Institute, Oregon State University, Newport, OR, USA.
  • Blumstein DT; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Science and Innovation Campus, Oxfordshire, UK.
  • Bors EK; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
  • Breeze CE; Department of Zoology and Entomology, University of Pretoria, Hatfield, South Africa.
  • Brooke RT; Busch Gardens Tampa, Tampa, FL, USA.
  • Brown JL; Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, CA, USA.
  • Carter G; The Rocky Mountain Biological Laboratory, Crested Butte, CO, USA.
  • Caulton A; Marine Mammal Institute, Oregon State University, Newport, OR, USA.
  • Cavin JM; Altius Institute for Biomedical Sciences, Seattle, WA, USA.
  • Chakrabarti L; Epigenetic Clock Development Foundation, Los Angeles, CA, USA.
  • Chatzistamou I; Center for Species Survival, Smithsonian National Zoo and Conservation Biology, Front Royal, VA, USA.
  • Chavez AS; Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH, USA.
  • Chen H; AgResearch, Invermay Agricultural Centre, Mosgiel, Otago, New Zealand.
  • Cheng K; Department of Biochemistry, University of Otago, Dunedin, Otago, New Zealand.
  • Chiavellini P; Gulf World Marine Park - Dolphin Company, Panama City Beach, FL, USA.
  • Choi OW; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
  • Clarke S; Department of Pathology, Microbiology & Immunology, School of Medicine, University of South Carolina, Columbia, SC, USA.
  • Cook JA; Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH, USA.
  • Cooper LN; Translational Data Analytics Institute, The Ohio State University, Columbus, OH, USA.
  • Cossette ML; Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN, USA.
  • Day J; Medical Informatics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • DeYoung J; Biochemistry Research Institute of La Plata, Histology and Pathology, School of Medicine, University of La Plata, La Plata, Argentina.
  • Dirocco S; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
  • Dold C; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Dunnum JL; AgResearch, Invermay Agricultural Centre, Mosgiel, Otago, New Zealand.
  • Ehmke EE; University of New Mexico, Department of Biology and Museum of Southwestern Biology, Albuquerque, NM, USA.
  • Emmons CK; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, USA.
  • Emmrich S; Department of Environmental & Life Sciences, Trent University, Peterborough, Ontario, Canada.
  • Erbay E; Taronga Institute of Science and Learning, Taronga Conservation Society Australia, Mosman, New South Wales, Australia.
  • Erlacher-Reid C; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
  • Faulkes CG; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Fei Z; SeaWorld Orlando, Orlando, FL, USA.
Science ; 381(6658): eabq5693, 2023 08 11.
Article en En | MEDLINE | ID: mdl-37561875
ABSTRACT
Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in HOXL subclass homeobox genes and developmental processes and is potentially regulated by pluripotency transcription factors. The methylation state of some modules responds to perturbations such as caloric restriction, ablation of growth hormone receptors, consumption of high-fat diets, and expression of Yamanaka factors. This study reveals an intertwined evolution of the genome and epigenome that mediates the biological characteristics and traits of different mammalian species.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Metilación de ADN / Epigénesis Genética / Mamíferos Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Humans Idioma: En Revista: Science Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Metilación de ADN / Epigénesis Genética / Mamíferos Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Humans Idioma: En Revista: Science Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos