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Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506.
Cole, Andrew G; Kultgen, Steven G; Mani, Nagraj; Quintero, Jorge G; Yi Fan, Kristi; Ardzinski, Andrzej; Stever, Kim; Dorsey, Bruce D; Phelps, Janet R; Lee, Amy C H; Thi, Emily P; Chiu, Tim; Tang, Sunny; Horanyi, Peter S; Mayclin, Stephen J; Harasym, Troy O; Sofia, Michael J.
Afiliación
  • Cole AG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA. Electronic address: acole@arbutusbio.com.
  • Kultgen SG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Mani N; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Quintero JG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Yi Fan K; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Ardzinski A; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Stever K; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Dorsey BD; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Phelps JR; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Lee ACH; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Thi EP; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Chiu T; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Tang S; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Horanyi PS; UCB Pharma, 87 Cambridge Park Drive, Cambridge, MA 02140, USA.
  • Mayclin SJ; UCB Pharma, 87 Cambridge Park Drive, Cambridge, MA 02140, USA.
  • Harasym TO; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
  • Sofia MJ; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
Bioorg Med Chem Lett ; 94: 129456, 2023 10 01.
Article en En | MEDLINE | ID: mdl-37633618
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Cápside / Proteínas de la Cápside Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Cápside / Proteínas de la Cápside Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article