TfOH-Catalyzed Cascade Reaction: Metal-Free Access to 3,3-Disubstituted Phthalides from o-Alkynylbenzoic Acids.
J Org Chem
; 88(18): 12924-12934, 2023 Sep 15.
Article
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| MEDLINE
| ID: mdl-37643422
ABSTRACT
A facile new method for the synthesis of 3,3-disubstituted phthalides is reported. A successive reaction process begins with the TfOH-catalyzed cyclization of o-alkynylbenzoic acids followed by an ortho-regioselective electrophilic alkylation of various electron-rich aromatic compounds or alkenes, which has been successfully developed. The corresponding regioselective products of 3-substituted phthalide were obtained in good to high yields.
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Colección:
01-internacional
Banco de datos:
MEDLINE
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En
Revista:
J Org Chem
Año:
2023
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Article