Tumor-Specific CD8<sup>+</sup> T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes.

Zawidzka, Elizabeth M; Biavati, Luca; Thomas, Amy; Zanettini, Claudio; Marchionni, Luigi; Leone, Robert; Borrello, Ivan

Tumor-Specific CD8⁺ T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes.

Zawidzka, Elizabeth M; Biavati, Luca; Thomas, Amy; Zanettini, Claudio; Marchionni, Luigi; Leone, Robert; Borrello, Ivan.

Afiliación

Zawidzka EM; Johns Hopkins University School of Medicine, Bloomberg Kimmel Institute for Cancer Immunotherapy.
Biavati L; Johns Hopkins University School of Medicine, Bloomberg Kimmel Institute for Cancer Immunotherapy.
Thomas A; Johns Hopkins University School of Medicine, Bloomberg Kimmel Institute for Cancer Immunotherapy.
Zanettini C; Weill Cornell Medical College.
Marchionni L; Weill Cornell Medical College.
Leone R; Johns Hopkins University School of Medicine, Bloomberg Kimmel Institute for Cancer Immunotherapy.
Borrello I; Johns Hopkins University School of Medicine, Bloomberg Kimmel Institute for Cancer Immunotherapy.

bioRxiv ; 2023 Aug 29.

Article en En | MEDLINE | ID: mdl-37693379

Palabras clave

T cell exhaustion; T cell persistence; TILs; adoptive cell therapy; bone marrow T cells

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article