Identification of a fundamental cryoinjury mechanism in MSCs and its mitigation through cell-cycle synchronization prior to freezing.

Johnstone, Brian H; Gu, Dongsheng; Lin, Chieh-Han; Du, Jianguang; Woods, Erik J

Johnstone, Brian H; Gu, Dongsheng; Lin, Chieh-Han; Du, Jianguang; Woods, Erik J.

Afiliación

Johnstone BH; Ossium Health, Inc., Indianapolis, IN, United States.
Gu D; Ossium Health, Inc., Indianapolis, IN, United States.
Lin CH; Ossium Health, Inc., Indianapolis, IN, United States.
Du J; Ossium Health, Inc., Indianapolis, IN, United States.
Woods EJ; Ossium Health, Inc., Indianapolis, IN, United States. Electronic address: erik@ossiumhealth.com.

Cryobiology ; 113: 104592, 2023 Dec.

Article en En | MEDLINE | ID: mdl-37827209

Asunto(s)

Criopreservación; Linfocitos T; Humanos; Congelación; Criopreservación/métodos; Proliferación Celular; Ciclo Celular; Supervivencia Celular

Palabras clave

Cell cycle; Cellular therapy; Cryogenic injury; Cryopreservation; DNA double-stranded breaks; DNA replication; Immune suppression; MSC; Serum starvation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T / Criopreservación Límite: Humans Idioma: En Revista: Cryobiology Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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