Co-expression of IL-4/IL-15-based inverted cytokine receptor in CAR-T cells overcomes IL-4 signaling in immunosuppressive pancreatic tumor microenvironment.

Zhou, Ying; Farooq, Muhammad Asad; Ajmal, Iqra; He, Cong; Gao, Yaoxin; Guo, Dandan; Duan, Yixin; Jiang, Wenzheng

Zhou, Ying; Farooq, Muhammad Asad; Ajmal, Iqra; He, Cong; Gao, Yaoxin; Guo, Dandan; Duan, Yixin; Jiang, Wenzheng.

Afiliación

Zhou Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
Farooq MA; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
Ajmal I; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
He C; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
Gao Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
Guo D; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
Duan Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
Jiang W; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China. Electronic address: wzjiang@bio.ecnu.edu.cn.

Biomed Pharmacother ; 168: 115740, 2023 Dec.

Article en En | MEDLINE | ID: mdl-37865999

Asunto(s)

Citocinas; Receptores Quiméricos de Antígenos; Línea Celular Tumoral; Citocinas/metabolismo; Inmunoterapia Adoptiva; Interleucina-15/metabolismo; Interleucina-4/metabolismo; Subfamilia K de Receptores Similares a Lectina de Células NK/genética; Subfamilia K de Receptores Similares a Lectina de Células NK/metabolismo; Receptores de Interleucina-15/metabolismo; Linfocitos T; Microambiente Tumoral; Humanos; Células HEK293

Palabras clave

CAR-T therapy; Inverted cytokine receptor (ICR); NKG2D-CAR-T; Pancreatic cancer; Tumor microenvironment

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Citocinas / Receptores Quiméricos de Antígenos Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article País de afiliación: China

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