Target Reserve and Turnover Parameters Determine Rightward Shift of Enalaprilat Potency From its Binding Affinity to the Angiotensin Converting Enzyme.

Nguyen, Van Anh; Zhang, Li; Kagan, Leonid; Rowland, Malcolm; Mager, Donald E

Nguyen, Van Anh; Zhang, Li; Kagan, Leonid; Rowland, Malcolm; Mager, Donald E.

Afiliación

Nguyen VA; Department of Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, USA.
Zhang L; Department of Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, USA.
Kagan L; Department of Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, USA; Department of Pharmaceutics and Center of Excellence for Pharmaceutical Translational Research and Education, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey
Rowland M; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Mager DE; Department of Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, USA; Enhanced Pharmacodynamics, LLC, Buffalo, NY, USA. Electronic address: dmager@buffalo.edu.

J Pharm Sci ; 113(1): 167-175, 2024 01.

Article en En | MEDLINE | ID: mdl-37871777

Asunto(s)

Enalaprilato; Peptidil-Dipeptidasa A; Humanos; Enalaprilato/farmacología; Peptidil-Dipeptidasa A/metabolismo; Inhibidores de la Enzima Convertidora de Angiotensina/farmacología; Unión Competitiva

Palabras clave

ACE inhibitor; Antagonism; Inhibitory potency; Target occupancy; Target-mediated drug disposition (TMDD)

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enalaprilato / Peptidil-Dipeptidasa A Límite: Humans Idioma: En Revista: J Pharm Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google