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Protocol of the IntenSify-Trial: An open-label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab-paclitaxel in patients with advanced stage or metastatic pancreatic ductal adenocarcinoma to evaluate the combination's pharmacokinetics, safety, and efficacy.
Hohmann, Nicolas; Sprick, Martin Ronald; Pohl, Moritz; Ahmed, Azaz; Burhenne, Jürgen; Kirchner, Marietta; Le Cornet, Lucian; Kratzmann, Markus; Hajda, Jacek; Stenzinger, Albrecht; Steindorf, Karen; Delorme, Stefan; Schlemmer, Heinz-Peter; Riethdorf, Sabine; van Schaik, Ron; Pantel, Klaus; Siveke, Jens; Seufferlein, Thomas; Jäger, Dirk; Haefeli, Walter E; Trumpp, Andreas; Springfeld, Christoph.
Afiliación
  • Hohmann N; Department of Medical Oncology, Heidelberg University Hospital, National Center for Tumor Diseases, Heidelberg, Germany.
  • Sprick MR; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Pohl M; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
  • Ahmed A; Institute of Medical Biometry, University Hospital Heidelberg, Heidelberg, Germany.
  • Burhenne J; Department of Medical Oncology, Heidelberg University Hospital, National Center for Tumor Diseases, Heidelberg, Germany.
  • Kirchner M; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Le Cornet L; Institute of Medical Biometry, University Hospital Heidelberg, Heidelberg, Germany.
  • Kratzmann M; NCT Trial Center, NCT, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hajda J; NCT Trial Center, NCT, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Stenzinger A; Pharmacovigilance Department, Coordination Centre for Clinical Trials (KKS), Heidelberg University Hospital, Heidelberg, Germany.
  • Steindorf K; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Delorme S; Division of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
  • Schlemmer HP; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Riethdorf S; Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • van Schaik R; Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Pantel K; Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Siveke J; Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Seufferlein T; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Jäger D; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK Partner Site Essen) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Haefeli WE; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
  • Trumpp A; Department of Medical Oncology, Heidelberg University Hospital, National Center for Tumor Diseases, Heidelberg, Germany.
  • Springfeld C; Clinical Cooperation Unit Applied Tumor Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Clin Transl Sci ; 16(12): 2483-2493, 2023 12.
Article en En | MEDLINE | ID: mdl-37920921
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Citostáticos Límite: Humans Idioma: En Revista: Clin Transl Sci Año: 2023 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Citostáticos Límite: Humans Idioma: En Revista: Clin Transl Sci Año: 2023 Tipo del documento: Article País de afiliación: Alemania