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IL-15-dependent immune crosstalk between natural killer cells and dendritic cells in HIV-1 elite controllers.
Hartana, Ciputra Adijaya; Lancien, Melanie; Gao, Ce; Rassadkina, Yelizaveta; Lichterfeld, Mathias; Yu, Xu G.
Afiliación
  • Hartana CA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Lancien M; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Gao C; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Rassadkina Y; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Lichterfeld M; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Yu XG; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: xyu@mgh.harvard.edu.
Cell Rep ; 42(12): 113530, 2023 12 26.
Article en En | MEDLINE | ID: mdl-38048223
ABSTRACT
As the principal effector cell population of the innate immune system, natural killer (NK) cells may make critical contributions to natural, immune-mediated control of HIV-1 replication. Using genome-wide assessments of activating and inhibitory chromatin features, we demonstrate here that cytotoxic NK (cNK) cells from elite controllers (ECs) display elevated activating histone modifications at the interleukin 2 (IL-2)/IL-15 receptor ß chain and the BCL2 gene loci. These histone changes translate into increased responsiveness of cNK cells to paracrine IL-15 secretion, which coincides with higher levels of IL-15 transcription by myeloid dendritic cells in ECs. The distinct immune crosstalk between these innate immune cell populations results in improved IL-15-dependent cNK cell survival and cytotoxicity, paired with a metabolic profile biased toward IL-15-mediated glycolytic activities. Together, these results suggest that cNK cells from ECs display a programmed IL-15 response signature and support the emerging role of innate immune pathways in natural, drug-free control of HIV-1.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Seropositividad para VIH Límite: Humans Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Seropositividad para VIH Límite: Humans Idioma: En Revista: Cell Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos