New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAF<sup>V600E</sup> and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study.

Fadaly, Wael A A; Nemr, Mohamed T M; Zidan, Taha H; Mohamed, Fatma E A; Abdelhakeem, Marwa M; Abu Jayab, Nour N; Omar, Hany A; Abdellatif, Khaled R A

New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAF^V600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study.

Fadaly, Wael A A; Nemr, Mohamed T M; Zidan, Taha H; Mohamed, Fatma E A; Abdelhakeem, Marwa M; Abu Jayab, Nour N; Omar, Hany A; Abdellatif, Khaled R A.

Afiliación

Fadaly WAA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Nemr MTM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Zidan TH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Mohamed FEA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Abdelhakeem MM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Abu Jayab NN; Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Omar HA; Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Abdellatif KRA; Pharmacology Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

J Enzyme Inhib Med Chem ; 38(1): 2290461, 2023 Dec.

Article en En | MEDLINE | ID: mdl-38061801

Asunto(s)

Antineoplásicos; Donantes de Óxido Nítrico; Ciclooxigenasa 2/metabolismo; Celecoxib; Estructura Molecular; Donantes de Óxido Nítrico/farmacología; Relación Estructura-Actividad; Aromatasa/metabolismo; Línea Celular Tumoral; Antiinflamatorios/farmacología; Triazoles/farmacología; Receptores ErbB/metabolismo; Apoptosis; Fluorouracilo; Simulación del Acoplamiento Molecular; Antineoplásicos/farmacología

Palabras clave

(EGFR) inhibition; Aromatase inhibition; B-RAFV600E; bis-Triazole; cyclooxygenase-2 inhibition; inhibition; nitric oxide donor

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Donantes de Óxido Nítrico / Antineoplásicos Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Egipto

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