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XAF1 promotes colorectal cancer metastasis via VCP-RNF114-JUP axis.
Xia, Ji; Ma, Ning; Shi, Qian; Liu, Qin-Cheng; Zhang, Wei; Cao, Hui-Jun; Wang, Yi-Kang; Zheng, Qian-Wen; Ni, Qian-Zhi; Xu, Sheng; Zhu, Bing; Qiu, Xiao-Song; Ding, Kai; Huang, Jing-Yi; Liang, Xin; Chen, Yu; Xiang, Yan-Jun; Zhang, Xi-Ran; Qiu, Lin; Chen, Wei; Xie, Dong; Wang, Xiang; Long, Lingyun; Li, Jing-Jing.
Afiliación
  • Xia J; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Ma N; Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Shi Q; Central Laboratory, The First Affiliated Hospital of Huzhou University , Huzhou, China.
  • Liu QC; Department of General Surgery, Fengxian Hospital Affiliated to Southern Medical University, Shanghai, China.
  • Zhang W; Department of General Surgery, Fengxian Hospital Affiliated to Southern Medical University, Shanghai, China.
  • Cao HJ; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Wang YK; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Zheng QW; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Ni QZ; School of Life Science and Technology, ShanghaiTech University , Shanghai, China.
  • Xu S; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Zhu B; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Qiu XS; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Ding K; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Huang JY; School of Life Science and Technology, ShanghaiTech University , Shanghai, China.
  • Liang X; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Chen Y; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Xiang YJ; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Zhang XR; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Qiu L; Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
  • Chen W; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Xie D; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Wang X; Institute of Clinical Medicine Research, Zhejiang Provincial People's Hospital, Hangzhou Medical College , Hangzhou, China.
  • Long L; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai, China.
  • Li JJ; School of Life Science and Technology, ShanghaiTech University , Shanghai, China.
J Cell Biol ; 223(2)2024 02 05.
Article en En | MEDLINE | ID: mdl-38095639
ABSTRACT
Metastasis is the main cause of colorectal cancer (CRC)-related death, and the 5-year relative survival rate for CRC patients with distant metastasis is only 14%. X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a zinc-rich protein belonging to the interferon (IFN)-induced gene family. Here, we report a metastasis-promoting role of XAF1 in CRC by acting as a novel adaptor of valosin-containing protein (VCP). XAF1 facilitates VCP-mediated deubiquitination of the E3 ligase RING finger protein 114 (RNF114), which promotes K48-linked ubiquitination and subsequent degradation of junction plakoglobin (JUP). The XAF1-VCP-RNF114-JUP axis is critical for the migration and metastasis of CRC cells. Moreover, we observe correlations between the protein levels of XAF1, RNF114, and JUP in clinical samples. Collectively, our findings reveal an oncogenic function of XAF1 in mCRC and suggest that the XAF1-VCP-RNF114-JUP axis is a potential therapeutic target for CRC treatment.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Péptidos y Proteínas de Señalización Intracelular / Proteínas Adaptadoras Transductoras de Señales / Proteínas Reguladoras de la Apoptosis Límite: Humans Idioma: En Revista: J Cell Biol Año: 2024 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Péptidos y Proteínas de Señalización Intracelular / Proteínas Adaptadoras Transductoras de Señales / Proteínas Reguladoras de la Apoptosis Límite: Humans Idioma: En Revista: J Cell Biol Año: 2024 Tipo del documento: Article País de afiliación: China