The efficacy of magnesium supplementation for gestational diabetes: A meta-analysis of randomized controlled trials.
Eur J Obstet Gynecol Reprod Biol
; 293: 84-90, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38128389
ABSTRACT
BACKGROUND:
The efficacy of magnesium supplementation is unclear for the treatment of gestational diabetes. This meta-analysis aimed to study the efficacy of magnesium supplementation for glycemic control and pregnant outcomes in women with gestational diabetes.METHODS:
Several databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases have been systematically searched up to July 2023, and we included randomized controlled trials (RCTs) assessing the efficacy of magnesium supplementation for gestational diabetes. The meta-analysis was performed using the random-effect model or fixed-effect model based on the heterogeneity.RESULTS:
Five RCTs and 266 patients were included in the meta-analysis. Overall, compared with control intervention for gestational diabetes, magnesium supplementation was able to significantly decrease FPG (MD = -7.33 mg/dL; 95 % CI = -7.64 to -7.02 mg/dL; P < 0.00001) and HOMA-IR (MD = -0.99; 95 % CI = -1.76 to -0.22; P = 0.01), but resulted in no obvious impact on serum insulin (MD = -4.17 µIU/mL; 95 % CI = -8.49 to 0.14 µIU/mL; P = 0.06), preterm delivery (OR = 0.42; 95 % CI = 0.06 to 2.95; P = 0.38), macrosomia (OR = 0.34; 95 % CI = 0.08 to 1.35; P = 0.13) or BMI change (MD = -0.01 kg/m2; 95 % CI = -0.06 to 0.04 kg/m2; P = 0.63).CONCLUSIONS:
Magnesium supplementation may be effective for the treatment of gestational diabetes without taking insulin treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Diabetes Gestacional
/
Insulinas
Tipo de estudio:
Systematic_reviews
Límite:
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
/
Eur. j. obstet. gynecol. reprod. biol
/
European journal of obstetrics gynecology and reproductive biology
Año:
2024
Tipo del documento:
Article
País de afiliación:
China